Methods and compounds for intensive skin repair and healing including active organic and synthetic compounds

ABSTRACT

A skin treatment compound includes Lidocaine and aloe vera. The aloe vera is Barbadensis Miller species. Optionally, the skin treatment compound includes Calendula. Alternatively, the skin treatment compound includes natural preservatives. Optionally, the natural preservatives include Leuconostoc/Radish Root Ferment Filtrate, Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle) Extract, Populus Tremuloides (Aspen) Bark Extract, and Gluconolactone.

TECHNICAL FIELD

The embodiments described herein include compounds and methods ofapplication for relief from irritation and pain from cancer radiationtreatments, shingles, tattoos, neuropathy, first and second degreeburns, and many other ailments.

BACKGROUND

Skin irritation in individuals is common, especially those undergoingcancer radiation treatments, as well as dealing with burns or othermaladies. Relieving the pain and speeding the healing of suchirritations is important to individuals. For health reasons, suchindividuals many times desire a primarily organic solution for aiding inthe healing of such skin irritations.

SUMMARY

Embodiments of the compounds and methods described herein aid in skinrepair and relieve irritation and pain that may result from varioustreatments including radiation, shingles, tattoos and tattoo removal,and neuropathy, among other ailments.

In one embodiment, a method for making a skin treatment compoundincludes making a Phase A portion of the skin treatment compoundincluding: mixing Ultrez powder with water to wet the Ultrez powder;adding glycerin; and heating and holding the Phase A portion at 170° F.Ultrez polymer is a hydrophobically modified cross-linked acrylatecopolymer (Acrylates/C10-30 Alkyl Acrylate Crosspolymer). The methodfurther includes making a Phase B portion of the skin treatment compoundincluding: adding lubricants; heating the Phase B portion at 170° F.;stirring the Phase B portion; and resting the Phase B portion for tenminutes. The method further includes mixing the Phase B portion with thePhase A portion. The method further includes adding sodium hydroxide tothe Phase B portion with the Phase A portion to form a Phase C portion.The method further includes making a Phase E portion of the skintreatment compound including: dissolving Vitamin C and Lidocaine inwater; adding a Phase D portion with Japanese Green Tea Extract, AloeVera Powder, and natural preservatives; and adding the Phase C portion.The method further includes mixing the resulting skin treatmentcompound. Optionally, the lubricants include at least one ingredientselected from a list consisting of Glyceryl Stearate, Stearic Acid,Cetyl Alcohol, Hi Oleic Safflower Oil, Rosehip Seed Oil, Vitamin E, andChia Seed Oil. Alternatively, the lubricants include Glyceryl Stearate,Stearic Acid, Cetyl Alcohol, Hi Oleic Safflower Oil, Rosehip Seed Oil,Vitamin E, and Chia Seed Oil. Optionally, the Phase D portion includesat least one botanical selected from a list consisting of ChamomillaRecutita (Matricaria) Extract, Calendula Officinalis (Calendula) FlowerExtract, Anthemis Nobilis (Roman Chamomile) Flower Extract, CentaureaCyanus (Cornflower) Flower Extract, Tilia Cordata (Linden) FlowerExtract, Hypericum Perforatum (St. John's Wort) Extract, Vitis Vinifera(Grapeseed) Extract, Tabebuia Impetiginosa (Pau d'Arco) Extract, andThymus Vulgaris (Thyme) Oil Extract. Alternatively, the Phase D portionincludes Chamomilla Recutita (Matricaria) Extract, Calendula Officinalis(Calendula) Flower Extract, Anthemis Nobilis (Roman Chamomile) FlowerExtract, Centaurea Cyanus (Cornflower) Flower Extract, Tilia Cordata(Linden) Flower Extract, Hypericum Perforatum (St. John's Wort) Extract,Vitis Vinifera (Grapeseed) Extract, Tabebuia Impetiginosa (Pau d'Arco)Extract, and Thymus Vulgaris (Thyme) Oil Extract. Optionally, thenatural preservatives include Leuconostoc/Radish Root Ferment Filtrate,Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium(Honeysuckle) Extract, Populus Tremuloides (Aspen) Bark Extract, andGluconolactone. In one alternative, the method further includesadjusting a pH of the skin treatment compound to between 6.8 and 7.2. Inone alternative, the method further includes adjusting a viscosity ofthe skin treatment compound to between 35,000 and 45,000 centipoise(cps) at 25° C.

In one embodiment, a skin treatment compound includes water; Ultrezpowder; glycerin; skin healing botanicals; sodium hydroxide; Vitamin C;Lidocaine; a Phase D portion; Japanese Green Tea Extract; Aloe VeraPowder; and natural preservatives. Optionally, the lubricatingingredients include at least one ingredient selected from a listconsisting of Glyceryl Stearate, Stearic Acid, Cetyl Alcohol, Hi OleicSafflower Oil, Rosehip Seed Oil, Vitamin E, and Chia Seed Oil.Alternatively, the lubricating ingredients include Glyceryl Stearate,Stearic Acid, Cetyl Alcohol, Hi Oleic Safflower Oil, Rosehip Seed Oil,Vitamin E, and Chia Seed Oil. In one alternative, the Phase D portionincludes at least one botanical selected from a list consisting ofChamomilla Recutita (Matricaria) Extract, Calendula Officinalis(Calendula) Flower Extract, Anthemis Nobilis (Roman Chamomile) FlowerExtract, Centaurea Cyanus (Cornflower) Flower Extract, Tilia Cordata(Linden) Flower Extract, Hypericum Perforatum (St. John's Wort) Extract,Vitis Vinifera (Grapeseed) Extract, Tabebuia Impetiginosa (Pau d'Arco)Extract, and Thymus Vulgaris (Thyme) Oil Extract. Optionally, the PhaseD portion includes Chamomilla Recutita (Matricaria) Extract, CalendulaOfficinalis (Calendula) Flower Extract. Anthemis Nobilis (RomanChamomile) Flower Extract, Centaurea Cyanus (Cornflower) Flower Extract,Tilia Cordata (Linden) Flower Extract, Hypericum Perforatum (St. John'sWort) Extract, Vitis Vinifera (Grapeseed) Extract, Tabebuia Impetiginosa(Pau d'Arco) Extract, and Thymus Vulgaris (Thyme) Oil Extract.Alternatively, the natural preservatives include Leuconostoc/Radish RootFerment Filtrate, Lonicera Japonica (Honeysuckle) Flower Extract,Lonicera Caprifolium (Honeysuckle) Extract, Populus Tremuloides (Aspen)Bark Extract, and Gluconolactone. Optionally, the natural preservativesinclude at least one botanical selected from a list consisting ofLeuconostoc/Radish Root Ferment Filtrate, Lonicera Japonica(Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle)Extract, Populus Tremuloides (Aspen) Bark Extract, and Gluconolactone.Optionally, a pH of the skin treatment compound is between 6.8 and 7.2.Alternatively, a viscosity of the skin treatment compound is between35,000 and 45,000 centipoise (cps) at 25° C.

In another embodiment, a skin treatment compound includes Lidocaine andaloe vera. The aloe vera is Barbadensis Miller species. Optionally, theskin treatment compound includes Calendula. Alternatively, the skintreatment compound includes natural preservatives. Optionally, thenatural preservatives include Leuconostoc/Radish Root Ferment Filtrate,Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium(Honeysuckle) Extract, Populus Tremuloides (Aspen) Bark Extract, andGluconolactone. Alternatively, the natural preservatives include atleast one botanical selected from a list consisting ofLeuconostoc/Radish Root Ferment Filtrate, Lonicera Japonica(Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle)Extract, Populus Tremuloides (Aspen) Bark Extract, and Gluconolactone.

In another embodiment, a method of treating skin irritation includestreating the skin irritation with an effective amount of a compound. Thecompound includes Lidocaine and aloe vera. The aloe vera is BarbadensisMiller species. Optionally, the skin treatment compound includesCalendula. Alternatively, the skin treatment compound includes naturalpreservatives. Optionally, the natural preservatives includeLeuconostoc/Radish Root Ferment Filtrate, Lonicera Japonica(Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle)Extract, Populus Tremuloides (Aspen) Bark Extract, and Gluconolactone.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows an exemplary method of making Phase A of a compound forintensive skin repair and healing;

FIG. 2 shows an exemplary method of making Phase B of a compound forintensive skin repair and healing;

FIG. 3 shows an exemplary method of making Phase C of a compound forintensive skin repair and healing; and

FIG. 4 shows an exemplary method of making Phase E and Phase F of acompound for intensive skin repair and healing.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Embodiments of methods and compounds are described for skin repair andhealing and relief from irritation and pain that may result from varioustreatments including radiation, shingles, tattoos and tattoo removal,neuropathy, or other skin-related issues, and are for illustrativepurposes only. The term the “compound” is used repeatedly herein. Theterm “compound” generally refers to the various embodiments describedherein that include in many embodiments a combination of ingredientsincluding Lidocaine, aloe vera (in many cases Barbadensis Millerspecies), and Calendula, as well as a combination of many otheringredients, and the scope of the coverage of the claims is onlyintended to be limited by the specifics of the claims and not theexamples described in relation to possible compounds. The compoundtypically is delivered in a cream or lotion form, but alternativeliquids or gels may be created. The following provides furtherdescription of certain embodiments of the methods and compounds. Asdescribed and claimed here, certain terms are defined and usedinterchangeably.

As used herein, the term “period of time” or “duration of time” meansmore than a single dosing, application, or administration of thecompound. More specifically, these terms mean the compound isadministered/applied one or more times per day over a period of seven ormore days, wherein generally no two consecutive days pass without theapplication of the compound and the individual applies the compound atleast three or four days in any seven-day period, more preferably fouror more days in any seven-day period, more preferably five or more daysin any seven-day period, more preferably six or more days in anyseven-day period, and most preferably seven consecutive days in anyseven-day period. For example, the individual can apply the compoundevery day, wherein the compound is applied multiple times over thecourse of the day or the individual may apply the compound a single timein a day.

As used herein, the term “effective amount” or “amount effective to”refers to an amount of the compound required to increase the healing ofskin and reduce pain or irritation of the skin. It will be understood bythose skilled in the art that a one time, single application ofembodiments of the compound may not be effective. Furthermore, it willbe understood by those skilled in the art that administering a singledose followed with multiple consecutive days of non-dosing ornon-supplementation will not achieve the effective amount as described.

This disclosure provides an important understanding of how the compoundmay provide healing and relief from pain and irritation when aneffective amount is applied to affected areas over a period of time.

In many embodiments, the compound includes ingredients of Lidocaine andaloe vera. In some alternatives, the specific species of BarbadensisMiller is used for the aloe vera. In many alternatives, Calendula isused as an ingredient as well. The addition of Calendula is thought tobe unique, as used in the combination of ingredients in the compound, asit has been studied in relation to radiation burns specifically. Each ofthe botanicals in the combination of ingredients has a property for skinhealth and healing. Note that the combination of botanicals providedherein, as well as the percentages of those botanicals, is merelyexemplary; and the exact percentages and botanicals used may change andstill be within the scope of the compound.

In many alternatives, another unique feature of the compound is that thecompound includes a combination of botanicals that serve as a naturalpreservative. By using the unique combination of preservatives, parabensor other unnatural chemicals are not needed. Furthermore, thecombination of botanical preservatives is organic, in the sense oftypical FDA standards. This allows the compound to be considered 95%organic, with the 5% Lidocaine being the only non-organic portion.

The compound has a variety of beneficial properties. It is applied likea cream on damaged or irritated areas. The Lidocaine portion of thecream is known to reduce pain. The aloe vera and Calendula speed healingof various skin injuries and maladies. The aloe vera and botanicals mayalso prevent breakdown of tissue after repeated radiation treatmentswhen used daily during the entire treatment cycle.

In some alternatives, the aloe vera is organic aloe Barbadensis Millerleaf juice (research has shown that it penetrates to the cellular leveland carries the other ingredients deeper into the tissues). Researchusing aloe vera on radiation burns has been conducted since the 1930s.According to dermatological research, aloe vera concentrate may helpreduce the incidence of skin breakdown, which is associated withrepeated radiation treatments. This makes the compound particularlyeffective at dealing with radiation burns and other radiation-relatedskin degradation. The compound also may be particularly effective forfirst-aid kit manufacturers for restaurant and industrial burns, as wellas dermatologists for use following dermabrasion treatments.

Many of the embodiments include the use of 4% Lidocaine. Lidocaine is apain relief ingredient and is optional in all formulations. Typically,pain relief aids in the healing process, since it prevents the patientor user from feeling the need to touch the affected area.

In one embodiment, the compound additionally includes one or moreingredients from the following list:

-   -   Glyceryl Stearate (Natural Skin Lubricant)    -   Stearic Acid (Plant-based Fatty Acid)    -   Carthamus Tinctorius (Safflower) Seed Oil    -   Rosa Canina (Rosehips) Fruit Oil    -   Sodium Ascorbyl Phosphate (Vitamin C)    -   Salvia Sinensis (Chia) Seed Oil    -   Vegetable Glycerin    -   Cetyl Alcohol (from Coconut Oil)    -   Carbomer (Natural Thickener)    -   Calendula Officinalis (Pot Marigold) Flower Extract    -   Chamomilla Recutita (Chamomile) Flower Extract    -   Matricaria Chamomilla (Roman Chamomile) Flower Extract    -   Tilia Officinalis (Linden) Extract    -   Hypericum Perforatum (St. John's Wort) Extract    -   Centaurea Cyanus (Cornflower) Extract    -   Vitis Vinifera (Grape) Seed Extract    -   Tabebuia Impetiginosa (Pau d'Arco) Extract    -   Camellia Oleifera (Japanese Green Tea) Leaf Extract    -   Tocopheryl Acetate (Vitamin E)

In many embodiments, a natural preservative is used. This naturalpreservative includes Leuconostoc/Radish Root Ferment Filtrate, whichfunctions as a natural preservative. The natural preservative furtherincludes Lonicera Japonica (Honeysuckle) Flower Extract, LoniceraCaprifolium (Honeysuckle) Extract, and Populus Tremuloides (Aspen) BarkExtract. The natural preservative also includes Gluconolactone, whichfunctions as a natural skin conditioner.

Various botanicals have been selected for inclusion in the uniquecompound. Chamomilla Recutita (Matricaria) extract is used because itmay function as a healing balm to treat burns, wounds, eczema, rashes,anal irritation, and sunburn. It has overall healing and soothingeffects.

Calendula Officinalis (Calendula) flower extract is used because it mayfunction as a soothing anti-inflammatory agent (high content ofpolysaccharides and terpinoids) and it has antiseptic properties. Theresulting compound may be used to treat eczema, burns, wounds, and othertypes of skin irritations. There are clinical studies that demonstratethat calendula can partially prevent some forms of acute dermatitisrelated to radiation therapy in breast cancer patients. It has beenshown to enhance collagen production and aid in preventing excessivescar development. It has a demonstrated ability to increase formation ofnew blood vessels. Bruises disperse much more quickly with applicationof this botanical. Last but not least, calendula is an immune stimulant.

Anthemis Nobilis (Roman Chamomile) flower extract is used because it mayfunction similarly to Matricaria in its properties. It is a soothing andcalming anti-inflammatory botanical.

Because of its gentle action, Centaurea Cyanus (cornflower) flowerextract is commonly used around the eyes for its antiseptic properties.Its soothing qualities and emolliency aids in treating aging skin.

Tilia Cordata (Linden) flower extract is used because it may have apositive effect on reducing cellulitis and edema. It has been shown todecrease dry skin as well as decrease the dark spots frequently seen onaging skin.

Hypericum Perforatum (St. John's Wort) extract is used because of itshistory of treating bruises, burns, sores, and sprains.

Neuralgia is used because it may have pain relieving activity related toflavonoid content. It has been shown to be active in preventing skininfections. It has strong antiviral activity, decreasing the appearanceof cold sores and fever blisters.

Vitis Vinifera (Grapeseed) extract is used because it contains highlevels of flavonoids and procyanidins. It is a very strong antioxidantand free radical destroyer. It has been shown to strengthen bloodvessels and increase circulation with a high content of resveratrolcontributing to overall vascular health as well as immune systemsupport.

Tabebuia Impetiginosa (Pau d'Arco) extract is used because it may haveboth anti-fungal and anti-viral properties. It has been used to treateczema and other forms of dermatitis. It also has been shown to reducepain and inflammation. It has been reputed to have anti-cancer effects,although the required dosage for this property has side effects.

Thymus Vulgaris (Thyme) extract is used because it may have antiseptic,antiviral, and antifungal properties. It has been shown to be effectivefor bruises and wounds. It has been used to treat cases of crabs andlice, as well as scabies. It is a strong antioxidant.

While there are certain similarities between many of the properties ofthese botanicals, there is believed to be interaction and possiblesynergy among them with regard to their remedial potential.

Example of Compound

In one embodiment, the compound may be made according to the followingprocess. The percentage of the total composition is shown in the firstcolumn and the named ingredient is listed in the second column. Thepreparation of the compound is listed as including Phases A-F.

PHASE A INCI NAME 68.86% Deionized Water Water 0.17% Ultrez 10 Carbomer1.00% Glycerin 99% Glycerin

FIG. 1 shows an exemplary method of preparing Phase A of the compound.In step 110, in a mixing tank large enough for the entire batch,deionized water is added. In step 120, slowly add the Ultrez 10 powderand allow it to wet. In step 130, once the Ultrez 10 powder is wetted,add the glycerin and mix slowly until the Ultrez 10 is totallydispersed. In step 140, heat and hold the mixture at 170° F., whilepreparing Phase B. Cover tank to avoid as much water loss as possible.

PHASE B INCI NAME 3.00% Glyceryl Stearate Glyceryl Stearate 3.00%Stearic Acid Stearic Acid 1.00% Cetyl Alcohol Cetyl Alcohol 1.50% HiOleic Safflower Oil Carthamus Tinctorius (Safflower) Seed Oil 1.00%Rosehip Seed Oil Rosa Canina (Rosehip) Fruit Oil 0.50% Vitamin ETocopheryl Acetate 1.00% Chia Seed Oil Salvia Sinensis (Chia) Seed Oil

FIG. 2 shows an exemplary method of preparing Phase B. In step 210, in atank large enough for Phase B, add the Phase B ingredients. In step 220,the mixture is heated to 170° F. In step 230, the mixture is stirred andthe temperature is held at 170° F. until all ingredients have melted andblended together. In step 240, the mixture is allowed to sit attemperature for an additional ten minutes. In step 250, the mixture isslowly added to Phase A with continued mixing until a smooth,well-blended emulsion has formed and the heat is turned off

PHASE C (premixed) INCI NAME 3.91% Sodium Hydroxide Sodium Hydroxide(10% aqueous solution)

FIG. 3 shows an exemplary method of preparing Phase C. In step 310,immediately the sodium hydroxide solution is added to the Phase A andPhase B, while stirring. In step 320, the emulsion should begin tothicken somewhat. Sodium hydroxide solutions are considerably exothermicand are most easily prepared before the rest of the mix is begun. Instep 330, the mixtures then is set aside to cool to room temperature andcovered until needed. 10% is w/w in this instance. The emulsion mustreach 104° F. before the addition of Phase E.

PHASE D (botanical compound)

0.10% Chamomilla Recutita (Matricaria) Extract

0.70% Calendula Officinalis (Calendula) Flower Extract

0.10% Anthemis Nobilis (Roman Chamomile) Flower Extract

0.10% Centaurea Cyanus (Cornflower) Flower Extract

0.10% Tilia Cordata (Linden) Flower Extract

0.05% Hypericum Perforatum (St. John's Wort) Extract

0.15% Vitis Vinifera (Grapeseed) Extract

0.10% Tabebuia Impetiginosa (Pau d'Arco) Extract

0.10% Thymus Vulgaris (Thyme) Oil Extract

In an exemplary embodiment, Phase D includes the above ingredients. Tomake Phase D, the extracts and mix are combined until an even dispersionis achieved. The combination will make up 1.00% of the entire formula.

PHASE E INCI NAME 0.01% Japanese Green Tea Extract Camellia OleiferaExtract 1.00% Vitamin Sodium Ascorbyl Phosphate 1.55% Organic 200X AloeVera Powder Aloe Barbadensis Inner Leaf Juice 5.00% Deionized WaterWater 4.00% Lidocaine Hydrochloride Lidocaine Hydrochloride 2.00%NataPres Preservative Leuconostoc/Radish Root Ferment Filtrate, LoniceraJaponica (Honeysuckle) Flower Extract, Lonicera Caprifolium(Honeysuckle) Extract, Populus Tremuloides (Aspen) Bark Extract, andGluconolactone

While Phases A+B+C are cooling, Phase E is prepared. FIG. 4 shows anexemplary embodiment of the process of making Phase E and completing themixture in Phase F. In step 410, in a separate container large enoughfor Phase E, Vitamin C and Lidocaine are dissolved in the deionizedwater. In step 420, after the ingredients are dissolved, the Phase Dmixture, Japanese Green Tea Extract, Aloe Vera Powder, and NataPres areadded. In step 430, the mixture is mixed well until evenly blended. Instep 430, once Phases A+B+C have reached a temperature of 104° F., PhaseE is slowly added to the A+B+C mixture in the tank. In step 440, themixture is mixed well for ten minutes or until well blended.

Phase F

Phase F includes quality control procedures for ensuring that theresulting compound is complete. Note that the compound typically isapplied in lotion or cream form. In step 450, the pH of the compound isadjusted. To do this, a sample is collected from the finished mixtureand taken to the quality control lab for inspection. The pH should bebetween 6.8 and 7.2. At times, homogenization of the compound may berequired. In step 460, the viscosity of the mixture is performed asneeded. The viscosity at 25° C. should be between 35,000 and 45,000centipoise (cps). Timings required for mixing are dependent on the tank,batch size, type of mixer, and speed of mixer.

Although the foregoing description is directed to certain embodiments,it is noted that other variations and modifications will be apparent tothose skilled in the art, and may be made without departing from thespirit or scope of the disclosure. Moreover, features described inconnection with one embodiment may be used in conjunction with otherembodiments, even if not explicitly stated above.

1.-26. (canceled)
 27. A skin treatment compound comprising: Lidocaine;and aloe vera, wherein the aloe vera is Barbadensis Miller.
 28. The skintreatment compound of claim 27, further comprising Calendula.
 29. Theskin treatment compound of claim 28, further comprising a naturalpreservative.
 30. The compound of claim 29, wherein the naturalpreservative comprises Leuconostoc/Radish Root Ferment Filtrate,Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium(Honeysuckle) Extract, Populus Tremuloides (Aspen) Bark Extract, andGluconolactone.
 31. The compound of claim 29, wherein the naturalpreservative comprises at least one botanical selected from the groupconsisting of Leuconostoc/Radish Root Ferment Filtrate, LoniceraJaponica (Honeysuckle) Flower Extract, Lonicera Caprifolium(Honeysuckle) Extract, Populus Tremuloides (Aspen) Extract, andGluconolactone.
 32. A method of treating skin irritation, the methodcomprising: treating the skin irritation with an effective amount of thecompound of claim
 27. 33. The method of claim 32, wherein the compoundfurther comprises Calendula.
 34. The method of claim 32, wherein thecompound further comprises a natural preservative.
 35. The method ofclaim 34, wherein the natural preservative comprises Leuconostoc/RadishRoot Ferment Filtrate, Lonicera Japonica (Honeysuckle) Flower Extract,Lonicera Caprifolium (Honeysuckle) Extract, Populus Tremuloides (Aspen)Bark Extract, and Gluconolactone.
 36. The method of claim 34, whereinthe natural preservative comprises at least one botanical selected fromthe group consisting of Leuconostoc/Radish Root Ferment Filtrate,Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium(Honeysuckle) Extract, Populus Tremuloides (Aspen) Extract, andGluconolactone.